![]() The reported adverse events of phenibut are just scratching surface of a largely unregulated online drug market with no standards of quality assurance. Signs of overdose include: shallow irregular breathing drowsiness and lethargy increased sweating decreasing blood pressure nausea and vomiting and lowering body temperature. These cases range from isolated symptoms of headaches, to a cluster of symptoms such as visual impairment, muscle spasms, palpitations and nausea/vomiting. Users may develop withdrawal effects, such as severe rebound anxiety and insomnia, when they stop taking the drug.ĭespite phenibut not being registered or legally available in Australia, the TGA has received three reports of problems related to phenibut use in the past five years. This can increase the risk of adverse effects. Users of phenibut can also develop tolerance within days, needing more of the drug to feel the same effects. These include gastrointesinal symptoms (nausea, vomiting, diarrhoea), central nervous system symptoms (insomnia, confusion, euphoria, depression, hallucinations), and visual disturbances and musculoskeletal symptoms (such as tremors). But because it has similar pharmacological properties to baclofen it’s likely to have similar side effects. There is currently limited information about phenibut. Side effects of phenibut are generally linked to its central nervous system depressant effects, such as sedation and problems with breathing. The drug used to be included in medical kits for cosmonauts on Russian space flights due to the reports of enhanced cognition and high tranquilising properties. In initial publications, phenibut was known as phenigamma. Phenibut was first synthesised in Russia in the 1960s by Vsevolod Vasilievich Perekalin and his associates at the Department of Organic Chemistry of the Herzen Pedagogical Institute in St Petersburg, Russia. Phenibut was available as a powder in amounts ranging from 5 g to 1,000 kg and as capsules containing 200–500 mg in packs of between six and 360. In Russia and the Ukraine, it is commercially available as БИФРЕН® (Bifren) and daily doses range from 500 to 2000 mg. ScreenshotĪlthough phenibut is commercially available in few countries around the world, aside from Russia, a recent study showed that 48 unrelated internet suppliers sold phenibut from the United Kingdom, United States, China, Australia and Canada. In Russia, Phenibut is sold commercially. In Australia specifically, the drug regulator, the Therapeutic Goods Administration (TGA) has rejected 11 public submissions for registration and states that phenibut “represents a significant risk of harm, including overdose”. Phenibut is not licenced for use in the European Union, Australia or the United States due to safety concerns. ![]() It is also used recreationally in many countries including the United States, United Kingdom and Australia to reduce social anxiety and induce feelings of euphoria.Īnimal studies also show it has potential to improve brain function after a stroke. Phenibut can be used to treat anxiety, post-traumatic stress disorder, alcohol withdrawal syndrome and vestibular (balance) disorders such as vertigo. ![]() Baclofen is prescribed as a muscle relaxant for patients with conditions such as multiple sclerosis. ![]() Phenibut is structurally similar to the widely prescribed drug baclofen (Lioresal), which is available in Australia. Because it depresses the central nervous system (like GABA), it is also used as a mood elevator and tranquiliser. ![]() Once phenibut reaches the brain the result is reduced anxiety and social inhibition. The blood-brain barrier is is an important mechanism that stops harmful toxins and bugs travelling through the blood stream and entering the brain.Įxplainer: what is the blood-brain barrier and how can we overcome it? Animal studies have shown that phenibut is able to penetrate the blood brain barrier. ![]()
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